The impact of the Human Genome Project on cancer research
The Human Genome Project, which operated from 1990 to 2003, provided researchers with basic information about the genetic content of the human organism, opening new avenues of discovery in fields such as cancer research.
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Transcript
The Human Genome Project was an international collaboration carried out from 1990 to 2003 that yielded the first full-length reference sequence of the human genome.
Following completion of the Project, scientists used cutting-edge DNA sequencing methods to analyze the human genome.
Some researchers, such as those involved in the Cancer Genome Project in the UK, looked specifically for changes, or mutations, associated with cancer. Cancer is characterized by the uncontrolled growth of abnormal cells in the body. Comparison of healthy human genomes against genomes of cancer cells isolated from patients facilitated the discovery of genes that are frequently mutated in cancer.
Some mutations were found to occur across cancer types, revealing patterns of mutation in cancer.
Many of the mutations were associated with changes in cell division, growth, and development. Scientists used this information to develop new drugs to target the malfunctioning proteins encoded by mutated genes.
Some of these novel drugs have proven highly effective against cancer. By slowing tumor growth and triggering cancer cell death, they have helped extend the lives of many cancer patients.
Some researchers, such as those involved in the Cancer Genome Project in the UK, looked specifically for changes, or mutations, associated with cancer. Cancer is characterized by the uncontrolled growth of abnormal cells in the body. Comparison of healthy human genomes against genomes of cancer cells isolated from patients facilitated the discovery of genes that are frequently mutated in cancer.
Some mutations were found to occur across cancer types, revealing patterns of mutation in cancer.
Many of the mutations were associated with changes in cell division, growth, and development. Scientists used this information to develop new drugs to target the malfunctioning proteins encoded by mutated genes.
Some of these novel drugs have proven highly effective against cancer. By slowing tumor growth and triggering cancer cell death, they have helped extend the lives of many cancer patients.
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