sigma factor
biochemistry
Quick Summary
The sigma factor is a protein crucial for initiating RNA synthesis in bacteria like E. coli. It works with the RNA polymerase enzyme to bind to the correct DNA sites, ensuring that transcription begins at the proper start of a gene. Once transcription is initiated, the sigma factor is released. Transcription factors, in general, control gene activity by regulating when, where, and how efficiently RNA polymerases function, playing vital roles in cellular functions and organism development.12
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