malate synthase
enzyme
Quick Summary
Malate synthase is an enzyme that plays a crucial role in the glyoxylate cycle. This cycle is an anaplerotic pathway, meaning it replenishes intermediates of the TCA cycle that are removed for biosynthesis. Specifically, malate synthase catalyzes the condensation of glyoxylate with acetyl coenzyme A (acetyl-CoA) to produce malate and coenzyme A. This reaction is essential for organisms that use two-carbon compounds, such as acetate, as their sole carbon source, enabling them to synthesize necessary building blocks for growth.1
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