isocitrate lysase
Quick Summary
Isocitrate lyase is an enzyme that plays a crucial role in the glyoxylate cycle. This cycle is an important metabolic pathway, particularly for microorganisms, that allows them to utilize simple carbon sources like acetate for growth.
The enzyme's primary function is to cleave isocitrate into succinate and glyoxylate. This reaction is essential for bypassing steps in the TCA cycle that would otherwise lead to the loss of carbon atoms as carbon dioxide. By enabling the net synthesis of four-carbon compounds from two-carbon units, isocitrate lyase allows organisms to conserve carbon and produce biosynthetic precursors when other metabolic pathways are unavailable.1
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metabolismAnaplerotic routes…oxalosuccinate, as occurs in [40], isocitrate is split by isocitrate lyase (reaction [52]), similar to reactions [4] and [15] of carbohydrate fragmentation. The dotted line in [52] indicates the way in which isocitrate is split. The products are succinate and glyoxylate.
Read More…oxalosuccinate, as occurs in [40], isocitrate is split by isocitrate lyase (reaction [52]), similar to reactions [4] and [15] of carbohydrate fragmentation. The dotted line in [52] indicates the way in which isocitrate is split. The products are succinate and glyoxylate.
Read More- metabolismPositive modulation
…enzyme of the glyoxylate cycle, isocitrate lyase, is allosterically inhibited by PEP and by pyruvate.
Read More…enzyme of the glyoxylate cycle, isocitrate lyase, is allosterically inhibited by PEP and by pyruvate.
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