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menopausal hormone therapy (MHT), treatment used to relieve symptoms associated with menopause, the life stage marked by the natural decline of ovarian hormone production. As levels of estrogen and progesterone fall, many individuals experience vasomotor symptoms (such as hot flashes and night sweats), sleep disturbance, mood changes, and genitourinary symptoms. Menopausal hormone therapy (MHT), sometimes referred to simply as hormone therapy, is given to restore concentrations of these hormones to physiologically active levels. MHT is...