Side effects of MHT may include breast tenderness, bloating, headache, and irregular bleeding. More-serious risks include increased chances of venous thromboembolism, in which a blood clot breaks free from its point of formation and becomes lodged in a blood vessel, and strokeβbrain injury incurred by lack of blood flow to the brain (often triggered by a thromboembolism). Age and timing of therapy initiation influence the risk of side effects.
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