fibrosis

pathology

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June 26, 2026

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Fibrosis is a medical condition characterized by the increase of interstitial fibrous tissue. This occurs when dense fibrous connective tissue replaces normal tissue, leading to stiffening and impaired function. A notable example is pulmonary fibrosis, where lung tissue is replaced by fibrous tissue, causing shortness of breath and dry cough. Fibroblasts, the primary cells of connective tissue, play a role in wound healing by depositing new collagen, the main structural protein in connective tissues. Fibrocartilage, a type of connective tissue, also contains collagen and provides structural support, particularly in the spine and joints.1234

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silicosis
…are all related to a fibrosis that reduces the elasticity of the lung. In the actual disease process, the tiny particles of inhaled silica are taken up in the lungs by scavenger cells, called macrophages, that serve to protect the body from bacterial invasion. Silica particles, however, cannot be digested…
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…are all related to a fibrosis that reduces the elasticity of the lung. In the actual disease process, the tiny particles of inhaled silica are taken up in the lungs by scavenger cells, called macrophages, that serve to protect the body from bacterial invasion. Silica particles, however, cannot be digested…
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asbestosis
…eventually cause excessive scarring and fibrosis, resulting in a stiffening of the lungs that continues long after exposure ceases. Greater effort is needed to make the stiffened lungs expand during breathing, which results in shortness of breath and inadequate oxygenation of the blood. Persons with advanced cases of the disease…
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…eventually cause excessive scarring and fibrosis, resulting in a stiffening of the lungs that continues long after exposure ceases. Greater effort is needed to make the stiffened lungs expand during breathing, which results in shortness of breath and inadequate oxygenation of the blood. Persons with advanced cases of the disease…
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renal system disease
Obstruction
…calculi and stricture (narrowing); by fibrosis—scarring—of surrounding tissue (retroperitoneal fibrosis); and by tumour, though this is more likely to cause blood in the urine (hematuria).
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…calculi and stricture (narrowing); by fibrosis—scarring—of surrounding tissue (retroperitoneal fibrosis); and by tumour, though this is more likely to cause blood in the urine (hematuria).
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