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Diphtheria toxoid is a weakened form of the diphtheria toxin that is used in vaccines to prevent the disease. In diphtheria, bacteria produce a toxin that causes illness. By treating this toxin with chemicals or heat, it becomes a harmless toxoid that can stimulate the body to produce antibodies.1

These antibodies can then neutralize the active toxin if a person is exposed to the actual diphtheria bacteria, thus providing immunity. Diphtheria toxoid is commonly produced by incubating the toxin with formaldehyde. It is often administered in combination with tetanus toxoid and pertussis vaccine (DTaP) or with tetanus toxoid alone (DT or Td). The introduction of diphtheria toxoid has significantly reduced the incidence of the disease worldwide.123

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