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anterior cruciate ligament (ACL), thick band of connective tissue that joins the femur to the tibia. Its primary function is to provide stability to the knee. Injuries to the anterior cruciate ligament (ACL) are among the most common types of trauma affecting the knee, being especially common among athletes who play such sports as football, basketball, and association football (soccer).

Anatomy and function

The ACL is one of two cruciate ligaments in the intercondylar region (the area between the condyles, the rounded ends of the bones) of the knee. The second cruciate ligament is known as the posterior cruciate ligament (PCL). The names of the two ligaments are derived from the Latin word cruciatus, meaning “crossed,” since they cross between the femur and the tibia. In the case of the ACL, anterior refers to the attachment of the ligament to the front portion of the tibia’s intercondylar area; by contrast, in the case of the PCL, posterior refers to the ligament’s connection to the rear portion of the tibia. The ACL is typically 26–38 mm (about 1–1.5 inches) in length and 10–12 mm (about 0.4–0.5 inch) in width, with its thickness tapering off as it descends to its point of attachment on the tibia.

There are two major bundles of fibers that make up the ACL: the anteromedial bundle (AMB) and the posterolateral bundle (PLB). When the knee is extended, the AMB is loose and the PLB tight. When the knee is flexed, the PLB loosens and the AMB tightens. Thus, regardless of the position of the knee, some portion of the ACL is under tension. This is critical to the function of the ACL in stabilizing the knee. For example, tension of the PLB prevents hyperextension of the knee. Other functions of the ACL include limiting tibial rotation and preventing excessive forward movement of the tibia relative to the femur.

A common injury with gender differences

While ACL injuries are very common among athletes, researchers have found that women are at greater risk than men. Megan Rapinoe is among the most notable women to rebound from these injuries: she had three ACL tears during a football (soccer) career in which she won two Women’s World Cup titles for the United States, an Olympic gold medal, and the Ballon d’Or Féminin.

Neymar, Lindsey Vonn, Sam Kerr, Patrick Mahomes, Rebecca Lobo, Alex Morgan, Rodri, and Tom Brady are among the many other notable athletes, women and men, who have experienced ACL injuries.

ACL injury

Sprains and tears are the most common types of injuries to the ACL. Such injuries commonly occur as a result of a sudden change in direction of movement or from sudden twisting, hyperextension of the knee joint, or impact from collision.

Treatment for ACL injury varies. A knee brace and physical therapy are usually sufficient for individuals with low activity levels. Athletes may undergo surgery to reconstruct the ligament. ACL injury is associated with a form of degenerative joint disease known as post-traumatic osteoarthritis of the knee.

Risk of ACL injury is increased by such factors as poor conditioning, atypical movement patterns during exercise, and ill-fitting footwear or sports equipment. Women are at higher risk of ACL injury than men, owing largely to the greater width of the female pelvis, which places increased stress on the soft tissues of the knee joint. Risk can be reduced through strengthening and conditioning exercises, especially those focused on the muscles of the upper legs and the abdomen.