Where do the axons of spiny striatal neurons project?

The axons of spiny striatal neurons project beyond the boundaries of the caudate nucleus and putamen. These neurons, which serve as the primary output pathway for the striatum, project in a specific pattern onto the globus pallidus and the substantia nigra.1

Within these projections, the spiny striatal neurons utilize the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), often in combination with other substances such as substance P and enkephalin.12