UBQLN2

…in a gene known as UBQLN2, which encodes a protein called ubiquilin 2. Ubiquilin 2 plays an important role in recycling damaged proteins from neurons in the spinal cord and neurons in the cortex and hippocampus of the brain. Similar to mutations in FUS/TLS and TDP43, mutations in UBQLN2 result…

…in a gene known as UBQLN2. The UBQLN2-encoded protein, ubiquilin 2, facilitates cellular recycling of damaged proteins in neurons in the spinal cord and the cortex and hippocampus of the brain. Mutation of the gene, however, causes damaged proteins to amass within the neurons. The researchers found defects in ubiquilin…