SOD1
Quick Summary
The SOD1 gene provides instructions for making an enzyme called superoxide dismutase. This enzyme acts as an antioxidant, protecting cells from damage caused by harmful molecules called free radicals, which are by-products of normal cell metabolism.123
In some cases of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, mutations in the SOD1 gene are linked to the condition. These mutations can impair the enzyme's ability to neutralize free radicals, potentially leading to the destruction of motor neurons. Familial ALS, which is inherited, accounts for about 5-10% of all ALS cases, and SOD1 mutations are found in approximately 20% of these familial cases.413
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- amyotrophic lateral sclerosisCauses of ALS
TDP43, and SOD1.
Read MoreTDP43, and SOD1.
Read More - Teepu SiddiqueResearch on ALS and other neurodegenerative disorders
… in a gene known as SOD1 (superoxide dismutase 1). SOD1 normally encodes an enzyme that neutralizes free radicals (potentially harmful by-products of cell metabolism). Siddique found, however, that its mutation resulted in the production of a defective version of the enzyme that led to the accumulation of free radicals in…
Read More… in a gene known as SOD1 (superoxide dismutase 1). SOD1 normally encodes an enzyme that neutralizes free radicals (potentially harmful by-products of cell metabolism). Siddique found, however, that its mutation resulted in the production of a defective version of the enzyme that led to the accumulation of free radicals in…
Read More