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transubstantiation, in Christianity, the change by which the substance (though not the appearance) of the bread and wine in the Eucharist becomes Christ’s real presence—that is, his body and blood. In Roman Catholicism and some other Christian churches, the doctrine, which was first called transubstantiation in the 12th century, aims at safeguarding the literal truth of Christ’s presence while emphasizing the fact that there is no change in the empirical appearances of the bread and...