What effects did Amazonian peoples associate with ayahuasca?

Amazonian Indigenous peoples have traditionally utilized ayahuasca as a sacred medicine and a tool for spiritual practice for centuries. Rather than viewing it through the lens of a "drug cult," these cultures associate the brew with profound spiritual and physical effects.123

Indigenous traditions often attribute healing powers to the potion. Shamans, or ayahuasceros, oversee its preparation and use, interpreting the common physical side effects—such as vomiting or diarrhea—as a necessary "purging" of negative energies from the body.13

Spiritually, the drink is known as the "vine of the soul" or "vine of the dead," reflecting its role in facilitating intense spiritual revelations. Users often report experiencing visions, a sensation of "rebirth," and a deeper understanding of themselves and the universe. While the brew is central to these traditional medicinal and spiritual practices, it is important to note that its use can also carry risks, including significant psychological distress.321