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The Treaty of Apamea, signed in 188 BCE, was a pivotal agreement between the Roman Republic and the Seleucid king Antiochus III the Great. This treaty concluded the Roman-Syrian War, significantly reshaping the political landscape of the Hellenistic world.12

Key terms of the treaty included:
* Antiochus III renounced all claims to territories west of the Taurus Mountains in Asia Minor.12
* The Seleucid kingdom was required to pay a substantial indemnity of 15,000 talents over 12 years.12
* Antiochus III had to surrender his war elephants and limit his fleet to ten ships.12
* Hostages, including his son, were to be provided to Rome.1

This treaty effectively ended Antiochus III's ambitions of challenging Roman dominance in Asia Minor and Europe, reducing the Seleucid Empire's territory and power. It marked a significant step in Rome's expansion and establishment of hegemony in the eastern Mediterranean.12

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