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Trail of Tears, in U.S. history, the forced relocation during the 1830s of Eastern Woodlands Indians of the Southeast region of the United States (including Cherokee, Creek, Chickasaw, Choctaw, and Seminole, among other nations) to Indian Territory west of the Mississippi River. Estimates based on tribal and military records suggest that approximately 100,000 indigenous people were forced from their homes during that period, which is sometimes known as the removal era, and that some 15,000...