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The Screwtape Letters, epistolary novel by C.S. Lewis, published serially in 1941 in the Guardian, a weekly religious newspaper. The chapters were published as a book in 1942 and extended in The Screwtape Letters and Screwtape Proposes a Toast in 1961.

Written in defense of Christian faith, this popular satire consists of a series of 31 letters in which Screwtape, an experienced devil, instructs his young charge, Wormwood, on effective strategies for tempting the human being assigned to him and making sure he continues on a steady path toward damnation. But confounded by church attendance and a faithful Christian woman, their efforts are defeated when their subject dies in a bombing raid with his soul at peace. Through his satiric use of the demonic narrative persona, Lewis examines the opposing sides in the battle between good and evil.

The book’s success begins with its witty use of ironic inversion: for example, God is “the Enemy,” Satan is “Our Father Below,” hierarchy becomes “Lowerarchy.” More important are its depth of spiritual understanding and keen psychological insights into human hypocrisies, lack of self-awareness, and actual motivations. The book was an immediate success, reprinted multiple times in its first year, and it was similarly successful when it was published in the United States in 1943. It was subsequently widely translated.

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