TRPA1

protein

Also known as: wasabi receptor

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Last updated

July 22, 2026

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TRPA1, also known as the "wasabi receptor," is a protein that functions as an ion channel. It is part of the transient receptor potential (TRP) channel superfamily, which plays a crucial role in sensory reception. TRPA1 is particularly known for its ability to sense noxious stimuli, including cold and pain.12

These channels are located in cell membranes and, when activated by stimuli like cold or irritants, they regulate the flow of ions (such as potassium, calcium, and sodium) into or out of cells. This ion flux can lead to an action potential, which is a nerve impulse that results in physiological sensation. Ardem Patapoutian's research contributed to the understanding of TRPA1's role in sensing irritants.231

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Ardem Patapoutian
…led to the discovery of TRPA1 (the so-called wasabi receptor), which acts as a sensor for noxious stimuli, including cold and pain.
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…led to the discovery of TRPA1 (the so-called wasabi receptor), which acts as a sensor for noxious stimuli, including cold and pain.
Read More