NOD2 References NOD2 gene variation Ask Anything Homework Help Also known as: nucleotide-binding oligomerization domain containing 2(Show More) Written by The Information Architects of Encyclopaedia Britannica The Information Architects maintain a master list of the topics included in the corpus of Encyclopædia Britannica, and create and manage the relationships between them. The Information Architects of Encyclopaedia Britannica Britannica AI Ask Anything Learn about this topic in these articles: inflammatory bowel diseaseVariation of a gene called NOD2 (nucleotide-binding oligomerization domain containing 2) also has been linked to Crohn disease, and variation of a gene called ECM1 (extracellular matrix protein 1) has been linked to ulcerative colitis. Read MoreVariation of a gene called NOD2 (nucleotide-binding oligomerization domain containing 2) also has been linked to Crohn disease, and variation of a gene called ECM1 (extracellular matrix protein 1) has been linked to ulcerative colitis. Read More