Meselson-Radding model

genetics

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July 22, 2026

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The Meselson-Radding model, proposed in 1975 by Matthew Meselson and Charles Radding, is a revised model of genetic recombination. Homologous recombination is the exchange of genetic material between DNA strands with similar base sequences. This process is crucial in eukaryotes during meiosis for DNA repair and increasing genetic diversity through chromosomal crossover. In bacteria, it aids in DNA repair and incorporates horizontally transferred genetic material.12

The Meselson-Radding model specifically addressed the formation of an asymmetric heteroduplex during recombination. General recombination, also known as homologous recombination, involves DNA molecules with long stretches of similar base sequences. It typically occurs during meiosis, viral infections, bacterial conjugation, and transformation. The process involves DNA cleavage, strand invasion, and the formation of a Holliday junction, ultimately leading to the shuffling and exchange of genetic segments.123

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Matthew Meselson
…model was known as the Meselson-Radding model. Meselson’s later work concentrated on the anomalous evolutionary success of bdelloid rotifers, a type of invertebrate that reproduces solely through asexual means.
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…model was known as the Meselson-Radding model. Meselson’s later work concentrated on the anomalous evolutionary success of bdelloid rotifers, a type of invertebrate that reproduces solely through asexual means.
Read More