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Indian Removal Act, (May 28, 1830), first major legislative departure from the U.S. policy of officially respecting the legal and political rights of the American Indians. The act authorized the president to grant Indian tribes unsettled western prairie land in exchange for their desirable territories within state borders (especially in the Southeast), from which the tribes would be removed. The rapid settlement of land east of the Mississippi River made it clear by the mid-1820s...