Hurler’s syndrome, one of several rare genetic disorders involving a defect in the metabolism of mucopolysaccharides, the class of polysaccharides that bind water to unite cells and to lubricate joints. Onset of the syndrome is in infancy or early childhood, and the disease occurs with equal

Scheie’s syndrome: A related condition is Hurler-Scheie syndrome (MPS I H S), which causes dwarfism, progressive blindness, deafness, and heart failure.

Scheie’s syndrome, uncommon hereditary metabolic disease characterized by clawing of the hands, corneal clouding, incompetence of the aortic valve of the heart, and painful nerve compression in the wrist (carpal tunnel syndrome). The disease was described by Harold Scheie of the United States in

Hunter’s syndrome, rare sex-linked hereditary disorder that varies widely in its severity but is generally characterized by some degree of dwarfism, mental retardation, and deafness. The disease affects only males and makes its first appearance during the first three years of life. Many patients

Sanfilippo’s syndrome, rare hereditary (autosomal recessive) metabolic disease characterized by severe mental retardation. There are three varieties, each caused by a defect in a different enzyme involved in the breakdown of mucopolysaccharides, a group of substances important in the structure and

Morquio syndrome, rare hereditary disorder of intracartilaginous bone development that results in severe malformation of the skeleton (particularly the spine and long bones) and dwarfing. The disease is recognized within the first two years of life and is usually progressive until bone growth

Maroteaux-Lamy syndrome, uncommon hereditary metabolic disease characterized by dwarfism, hearing loss, and progressive skeletal deformity. Onset of the disease is usually in early childhood, with some coarsening of facial features evident by the first birthday. Eye changes, consisting of corneal

end-plate potential: …a slight depolarization, called a miniature end-plate potential (MEPP). One hundred to 200 quanta, released simultaneously or in rapid series by a nerve impulse, cause multiple MEPPs, which summate, or combine, to produce an EPP. If the EPP depolarizes the cell to a crucial threshold level, it will fully activate…

parkinsonism: …neurotoxin known as MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), previously found in contaminated heroin, also causes a form of toxin-induced parkinsonism. The ability of this substance to destroy neurons suggests that an environmental toxin similar to MPTP may be responsible for Parkinson disease. Pugilistic parkinsonism results from head trauma and has affected professional…

historiography: The presentation of history: …lure of the “MPU,” or minimum publishable unit—the smallest bit of a project that an editor will accept and that, duly noted in a curriculum vitae, will reassure department chairs or funding agencies of one’s continuing scholarly vitality.

Mpumalanga, province, northeastern South Africa. It is bounded by Limpopo province to the north, the countries of Mozambique and Eswatini to the east, the provinces of KwaZulu-Natal and Free State to the south, and Gauteng province to the west. Mpumalanga province (called Eastern Transvaal province

unmanned aerial vehicle: …development of these aircraft—is the MQ-1 Predator, which first flew in 1994 and entered service the following year. The Predator, with a length of 26 feet 8 inches (8 metres) and a wingspan of 41 feet 8 inches (12.5 metres), is powered by a piston engine driving a pusher propeller.…

military aircraft: Unmanned aerial vehicles (UAVs): The much larger Northrop Grumman MQ-8 Fire Scout, a 3,150-pound (1,420-kg) single-rotor craft resembling an unmanned helicopter, has been operational with the U.S. Navy since 2009; it was first used in anti-drug-smuggling operations off the coasts of the United States.

unmanned aerial vehicle: …derivative of the Predator, the MQ-9 Reaper, has improved performance and carries a larger ordnance load. Both the Predator and the Reaper have been used in the conflicts in Iraq and Afghanistan and have been purchased by allies of the United States.

S.E.K. Mqhayi was a Xhosa poet, historian, and translator who has been called the “father of Xhosa poetry.” Mqhayi, who was born into a family of long Christian standing, spent several of his early years in rural Transkei, a circumstance that is reflected in his evident love of Xhosa history and

S.E.K. Mqhayi was a Xhosa poet, historian, and translator who has been called the “father of Xhosa poetry.” Mqhayi, who was born into a family of long Christian standing, spent several of his early years in rural Transkei, a circumstance that is reflected in his evident love of Xhosa history and

Mount Kazbek, mountain in northern Georgia. One of the country’s highest peaks, Mount Kazbek attains an elevation of 16,512 feet (5,033 meters). It is an extinct volcano with a double conical form and lava flows up to 1,000 feet (300 meters) thick. It is covered by icefields from which rise the

Pakistan: Zia-ul-Haq: …and the formation of the Muhajir Qaumi Movement (MQM) in the mid-1980s was both a cause and a consequence of the violence that was directed against the immigrant community. The founding of the MQM and its increasingly militant posture aroused the native Sindhis as never before. The Sindhi complaint that…

measles: Measles vaccine and eradication efforts: …agents, specifically with rubella (MR), mumps and rubella (MMR), or mumps, rubella, and varicella (MMRV). The vaccines typically are given in two doses. In the United States, for example, the first dose is given at 12 to 15 months of age, and the second dose is recommended at four…

Adam Brody: Stardom: From The O.C. to movies: …Grind (2003), Missing Brendan (2003), Mr. & Mrs. Smith (2005), and Thank You for Smoking (2005). Following the end of The O.C. in 2007, Brody, by his own admission, became somewhat picky about his roles, seeking subject matter that appealed to his sensibilities and breaking away from teen drama typecasting.

Michaela Coel: Other projects from the 2020s: …reboot of the spy series Mr. & Mrs. Smith, for which she won an Emmy Award for outstanding guest actress in a drama. In 2021 Coel published an expanded version of her MacTaggart Lecture as Misfits: A Personal Manifesto. The following year she and her I May Destroy You costar…

Suryakumar Yadav is an Indian cricket player who bats right-handed and occasionally bowls right-arm off-spin. He primarily represents the national team in the Twenty20 (T20) format. He is regarded as an expert in 360-degree batting, an attacking style that uses a wide range of strokes to score runs

Alan Ayckbourn: Singular (1974), Intimate Exchanges (1985), Mr. A’s Amazing Maze Plays (1989), Body Language (1990), Invisible Friends (1991), Communicating Doors (1995), Comic Potential (1999), The Boy Who Fell into a Book (2000), and the trilogy Damsels in Distress (2002). In 2002 he published

comic strip: The United States: Mutt (later Mutt and Jeff). At first set in a horse-racing milieu, it soon became a general interest comic.

bodybuilding: …until the inception of the Mr. America contest in 1939 under the auspices of the Amateur Athletic Union (AAU) of the United States. Thereafter, Mr. America winners John Grimek (1940–41) and Steve Reeves (1947) served as role models for a generation of aspiring bodybuilders. The sport developed quickly after World…

Madhubala: Rising popularity and stardom: …naïve heiress in the comedy Mr. and Mrs. ’55 (1955), directed by and costarring Guru Dutt; a young woman raised by poor itinerants in the dramedy Phagun (1958; “Spring”), popular for its songs and with Bharat Bhushan as the male lead; a fearless reporter in the thriller Kala Pani (1958;…

Mr. and Mrs. Andrews, oil painting created about 1750 by English artist Thomas Gainsborough. It has been called his first masterpiece, painted early in his career. It shows his blossoming talent, not just as a portraitist but also as a landscape painter, the two genres for which he was best known.

Ruth Prawer Jhabvala: … (1965), Heat and Dust (1983), Mr. & Mrs. Bridge (1990), Jefferson in Paris (1995), and adaptations of Henry James’s The Europeans (1979), The Bostonians (1984), and The Golden Bowl (2000).

Alfred Hitchcock: The Hollywood years: Rebecca to Dial M for Murder: The screwball comedy Mr. and Mrs. Smith (1941) was Hitchcock’s first change of pace since coming to Hollywood. The film starred Carole Lombard and Robert Montgomery as the eponymous bickerers who discover that their marriage is legally invalid. It was a box-office success but was Hitchcock’s last comedy…

Orson Welles: Films of the 1950s: Othello, Mr. Arkadin, and Touch of Evil: Mr. Arkadin (1955; also called Confidential Report) was based on an original story by Welles and was financed by European investors, who removed him from the film during editing. It is a Citizen Kane-like story with a different but equally tragic ending: the wealthy and…

Rowan Atkinson: Mr. Bean and international fame: …led to the television program Mr. Bean (1990–95), which starred the rubber-faced Atkinson as a pratfalling, nearly mute buffoon, bumbling his way through everyday situations made comedic by his clumsiness and scheming. Transcending both the traditional boundaries of English humor and the verbal repartee of Blackadder, the working-class Bean attracted…

Rowan Atkinson: Mr. Bean and international fame: …central plot device, and later Mr. Bean’s Holiday (2007), in which the eponymous antihero takes on France. The character also inspired an animated television series in 2002. Atkinson appeared as Mr. Bean in a skit during the opening ceremony of the 2012 Summer Olympics in London.

Virginia Woolf: Mrs. Dalloway, To the Lighthouse, A Room of One’s Own and other major works of Virginia Woolf: …as the Hogarth Press pamphlet Mr. Bennett and Mrs. Brown. In it she celebrated the breakdown in patriarchal values that had occurred “in or about December, 1910”—during Fry’s exhibit “Manet and the Post-Impressionists”—and she attacked “materialist” novelists for omitting the essence of character.

Mr. Blandings Builds His Dream House, American romantic comedy film, released in 1948, that offered a humorous look at the frustrations of owning a home. Cary Grant and Myrna Loy played a Manhattan couple who, tired of city life, decide to build a house in the country. The process, however, is

J.R.R. Tolkien: Other works: Tolkien (1981), the children’s stories Mr. Bliss (1982) and Roverandom (1998), and The Legend of Sigurd and Gudrún (2009), two narrative poems drawn from northern legend and written in the style of the Poetic Edda. The Fall of Arthur (2013) is an unfinished verse exploration of Arthurian legend inspired by…

Evan S. Connell: Ten years later Connell published Mr. Bridge (1969), which relates the same story from the point of view of the husband. Both novels, which were among Connell’s most-successful works, were adapted as the film Mr. and Mrs. Bridge (1990). Son of the Morning Star: Custer and the Little Bighorn (1984;…

H.G. Wells: Middle and late works: His next novel, Mr. Britling Sees It Through (1916), though touched by the prejudice and shortsightedness of wartime, gives a brilliant picture of the English people in World War I.

Demi Moore: Movies in the 2000s and marriage to Ashton Kutcher: …Throttle (2003), Bobby (2006), and Mr. Brooks (2007). Meanwhile, she began dating the younger actor Ashton Kutcher in 2003, causing a stir in tabloids because of their 15-year age difference. They married in 2005 and were expecting a child when Moore had a late miscarriage. By then she had begun…

Peter Ackroyd: … (2006), Three Brothers (2013), and Mr. Cadmus (2020). In 2009 Ackroyd also published a retelling of The Canterbury Tales.

Christopher Paul Curtis: ” Mr. Chickee’s Funny Money (2005) details the adventures of Steven Carter, an overachieving seven-year-old who aspires to become a detective.

Eddie Murphy: …A Thousand Words (2012), and Mr. Church (2016). In the biopic Dolemite Is My Name (2019), he played comedian and actor Rudy Ray Moore, who was a blaxploitation star in the 1970s. After an absence of 35 years, Murphy returned to Saturday Night Live in 2019, and, for his performance…

Anne Moody: In 1975 Moody published Mr. Death: Four Stories. She began writing a sequel to Coming of Age in Mississippi, Farewell to Too Sweet, in 1976, the year of her mother’s death, but the book remained unpublished.

Mr. Deeds Goes to Town, American romantic comedy film, released in 1936, that became one of director Frank Capra’s most popular movies. It is noted for its populist theme and for the performances of Gary Cooper and Jean Arthur. Longfellow Deeds (played by Cooper) is a country rube who, after

Benson Boone: Reception: …video for his single “Mr. Electric Blue,” released in 2025. Presenting more of a skit than a music performance, the video shows Boone confronting executives at Industry Plant Records (referring to the accusation that Boone was “planted” by the music industry rather than being an authentic success) while wearing…

Ray Bradbury: Early life: …encounter with a carnival magician, Mr. Electrico, in 1932 as a notable influence. Wreathed in static electricity, Mr. Electrico touched the young Bradbury on the nose and said, “Live forever!” The next day, Bradbury returned to the carnival to ask Mr. Electrico’s advice on a magic trick. After Mr. Electrico…

Sammy Davis, Jr. was an American singer, dancer, actor, and entertainer who broke down barriers for African American performers in the 20th century. Considered a consummate showman, he earned the nickname “Mr. Entertainment” for his versatile talents and his seemingly boundless energy on the stage

Nick Joaquin: Guevara Story (1993), and Mr. F.E.U., the Culture Hero That Was Nicanor Reyes (1995).

Fantastic Four: Origins: …a quartet of new characters: Dr. Reed Richards, a pompous scientist; Sue Storm, his lovely and somewhat reserved fiancée; Sue’s hotheaded teenaged brother Johnny Storm; and Richards’s beefy longtime friend pilot Ben Grimm. The foursome commandeered an untested spaceship of Richards’s design from the U.S. military in a frantic but…

Traffic: …songs on their debut album, Mr. Fantasy (1967), which reached the British Top Ten. Mason departed briefly, returning just long enough to write half of the songs on Traffic (1968)—a hit in both the United Kingdom and the United States—before being fired.

Mr. Flood’s Party, rhymed narrative poem by Edwin Arlington Robinson, published in his Collected Poems (1921) and considered one of his finest works. The poem is set in the fictional Tilbury Town. The narrative concerns lonely, isolated Eben Flood, resident of Tilbury Town, who climbs a hill above

The Berlin Wall was erected by communist East Germany and the Soviet Union in 1961 to keep skilled East German workers and intellectuals from fleeing to West Berlin (an urban enclave administered by the United States, Great Britain, and France). By the 1980s it had become a symbol of the tense

John Mellencamp: of Van Morrison’s “Wild Night”; Mr. Happy Go Lucky (1996), featuring the hit single “Key West Intermezzo (I Saw You First)”; the self-titled John Mellencamp (1998); and Trouble No More (2003), an album of stripped-down covers that topped the blues charts. Freedom’s Road (2007) yielded the minor hit “Our Country.”…

Richard Dreyfuss: 1990s and beyond: …to teach high school in Mr. Holland’s Opus (1995) earned Dreyfuss another Oscar nomination.

Laura Linney: …Sherlock Holmes (Ian McKellen) in Mr. Holmes (2015). Her credits from 2016 included the action spectacle Teenage Mutant Ninja Turtles: Out of the Shadows; Sully, about US Airways flight 1549, which crash-landed in the Hudson River; and Tom Ford’s thriller Nocturnal Animals. Linney then was cast in The

Shekhar Kapur: Rise to prominence and international acclaim: Kapur’s next film was Mr. India (1987), a sci-fi superhero story about a man (played by Anil Kapoor) who inherits an invisibility device. The film had been written by the prominent scriptwriting duo Salim Khan-Javed Akhtar before their split in the mid-1980s. Mr. India was a huge success, and…

F. Marion Crawford: …India provided the inspiration for Mr. Isaacs (1882). This story, the tale of a diamond merchant whose sale of a unique stone brings protest from Britain, marked the beginning of Crawford’s prosperous career.

Peter Bogdanovich: The 1980s and beyond: …cast in such movies as Mr. Jealousy (1997), Infamous (2006), and While We’re Young (2014). His notable roles on television included that of a psychiatrist on the HBO series The Sopranos.

Bruce Catton: …the Army of the Potomac: Mr. Lincoln’s Army (1951), Glory Road (1952), and A Stillness at Appomattox (1953). The latter earned him both a Pulitzer Prize and a National Book Award in 1954.

Colin MacInnes: Mr. Love and Justice: Criminality and vice are leitmotifs in both City of Spades and Absolute Beginners, but they take centre stage in Mr. Love and Justice (1960). In it MacInnes once again tells his story from two perspectives, this time those of a cop…

Jennifer Garner: Early roles and marriage to Scott Foley: …Washington Square and the comedy Mr. Magoo (both 1997). She was cast in 1998 on the TV series Significant Others and in 1999 on the Party of Five spin-off, Time of Your Life, but both shows were canceled after a few episodes. Garner had a guest appearance in 1998 on…

Dustin Hoffman: … (2006) and the children’s fantasy Mr. Magorium’s Wonder Emporium (2007). Hoffman and Stranger Than Fiction costar Emma Thompson played lonely strangers who fall in love in Last Chance Harvey (2008). He reprised his Meet the Fockers role in its sequel, Little Fockers (2010), and later appeared as the title character’s…

Richard Fleischer: Later work: …largely unsuccessful films, Fleischer directed Mr. Majestyk (1974), in which Charles Bronson starred as a watermelon farmer who becomes targeted for a gang hit and inventively fights back; its screenplay was written by Elmore Leonard.

Ted Danson: Career: >Mr. Mayor (2021–22), and A Man on the Inside (2024– ). He made a cameo appearance in the war film Saving Private Ryan (1998).

Stephen King: Serial novels: King’s Mr. Mercedes (2014), Finders Keepers (2015), and End of Watch (2016) form a trilogy of hard-boiled crime novels centering on retired detective Bill Hodges. The trilogy was adapted into a TV series in 2017–19, starring Brendan Gleeson as Hodges. King also wrote a serial novel,…

David E. Kelley: …created and cowrote the series Mr. Mercedes (2017–19), which was based on a novel by Stephen King about a serial killer being hunted by a retired detective.

Michael Keaton: Comedy hits: Night Shift, Mr. Mom, and Beetlejuice: Other comedy hits followed, notably Mr. Mom (1983), Johnny Dangerously (1984), Gung Ho (1986), and the Tim Burton horror-comedy Beetlejuice (1988), in which Keaton costarred with Alec Baldwin, Geena Davis, and Winona Ryder and appeared in the title role as an obnoxious

Kendrick Lamar: Making history with DAMN.: …released his fifth studio album, Mr. Morale & the Big Steppers. The 18-track recording features collaborations with a diverse range of musicians and was lauded for its complexity and introspection. It won Grammys for best rap album, rap song, and rap performance; the latter two awards were for “The Heart…

R. Crumb: …in his comic stories featuring Mr. Natural, a cynical and mercenary guru. As the counterculture movement subsided, Crumb curtailed his output, stopping altogether in 1976. Plagued by troubles with the Internal Revenue Service (IRS), he lived in seclusion for several years and then resurfaced in 1981, when he published the…

Grandmaster Flash and the Furious Five: Ness (also called Scorpio; original name Eddie Morris), and Raheim (original name Guy Williams).

Jared Leto: Dallas Buyers Club and later roles: …starring in the Belgian drama Mr. Nobody (2009), Leto ceased acting for several years to focus on his music career. He returned to the big screen in 2013 with a performance as the AIDS-stricken transgender woman Rayon in Dallas Buyers Club, which brought him both a Golden Globe and an…

D.H. Lawrence: Later life and works: …Rod (1922), and the uncompleted Mr. Noon (published in its entirety only in 1984). All three novels are in two parts: one set in Eastwood and sardonic about local mores, especially the tribal ritual of finding a mate, the other set in Europe, where the central figure breaks out of…

The Berlin Stories: …the semiautobiographical work consists of Mr. Norris Changes Trains (1935; U.S. title, The Last of Mr. Norris) and Goodbye to Berlin (1939).

Mr. Olympia, annual bodybuilding competition sanctioned by the International Fitness and Bodybuilding Federation (formerly the International Federation of BodyBuilders). It was first held in 1965 in Brooklyn, New York, but it has grown into a global contest hosted by cities around the world and

Stephen Colbert: Other work: Aliens (2009), Mr. Peabody & Sherman (2014), and Despicable Me 4 (2024). He coauthored Wigfield (2003) with Sedaris and Dinello and starred with them in a feature film adaptation of Strangers with Candy (2005). In 2007 Colbert published I Am America (And So Can You!), in which…

Irving Pichel: Directing: Pichel rebounded with the delightful Mr. Peabody and the Mermaid (1948). William Powell was cast as a married man who lands a comely mermaid (Ann Blyth) while fishing, complicating his life. (Ron Howard’s 1984 comedy Splash is clearly indebted to Pichel’s film.)

Tony Randall: …Weskit in the TV series Mr. Peepers, which ran until 1955. Onstage he appeared in Oh, Men! Oh, Women! (1954), and in 1957 he began his Hollywood career with the film version of that play. Roles in three Rock Hudson–Doris Day films—Pillow Talk (1959), Lover Come Back

Arthur Miller: …Ride Down Mount Morgan (1991), Mr. Peters’ Connections (1998), and Resurrection Blues (2002).

Danny Glover: …Revolt (2013), Waffle Street (2015), Mr. Pig (2016), and Jumanji: The Next Level (2019). Glover made his feature-film directorial debut with Just a Dream in 2002.

children’s literature: Peaks and plateaus (1865–1940): Their isolated effort, Mr. Popper’s Penguins (1938), will last as a masterpiece of deadpan humor that few children or adults can resist. The third writer is Laura Ingalls Wilder. Her Little House books, nine in all, started in 1932 with The Little House in the Big Woods. The…

Jim Carrey: Eternal Sunshine of the Spotless Mind and later films: In the family comedy Mr. Popper’s Penguins (2011), based on the children’s book of the same name, Carrey portrayed a businessman who inherits several gentoo penguins. His later credits included The Incredible Burt Wonderstone (2013), Kick-Ass 2 (2013), and Dumb and Dumber To (2014).

John Chamberlain: Chamberlain’s sculptures are typified by Mr. Press (1961), a construction of fragments from automobiles, crumpled and jammed together to create an effect of isolated, frozen movement. He often coated his pieces with bright industrial paints. During the 1970s oil crisis, Chamberlain often incorporated oil barrels into his work, notably in…

Richard Baxter: His autobiographical Reliquiae Baxterianae, or Mr. Richard Baxter’s Narrative of the Most Memorable Passages of His Life and Times (1696), still of interest, gives an account of his inner spiritual struggles.

Sam Rockwell: …in the comedy action romance Mr. Right (2015).

Jack Lemmon: …performance as Ensign Pulver in Mister Roberts (1955) firmly established him as one of the screen’s brightest new comic actors. He went on to deliver solid performances in other comedies, including My Sister Eileen (1955), Operation Mad Ball (1957), Bell, Book and Candle (1958), and It Happened to Jane (1959),…

Rami Malek: Stardom: Mr. Robot and Bohemian Rhapsody: …role of Elliot Alderson in Mr. Robot. Malek’s character is an asocial cybersecurity engineer and hacker who joins a group determined to overthrow corporate America. The show debuted in 2015 and was a huge success. Malek earned particular praise for his complex portrayal of the brilliant, alienated Alderson, and in…

Mr. Sammler’s Planet, novel by Saul Bellow, published in 1970. It won the National Book Award for fiction in 1971. The setting is New York City during the politically tumultuous late 1960s. The intellectual Mr. Sammler, an elderly Polish Holocaust survivor, has been damaged both physically and

William Castle: King of the Gimmick: …returned to period movies with Mr. Sardonicus (1961), in which a disfigured, evil count (played by Guy Rolfe) has his fate decided at film’s end by the audience’s vote during a “Punishment Poll.” Such innovative promotional campaigns gave Castle the nickname “King of the Gimmick.”

Billy Crystal: …his film directorial debut with Mr. Saturday Night, a dramedy that centred on the life of a fading stand-up comedian, which he also cowrote, produced, and starred in. After a series of flops that included his second effort in the director’s chair, Forget Paris (1995), Crystal gained acclaim for Analyze…

Sarah Silverman: …on the sketch comedy program Mr. Show with Bob and David. She also made a number of appearances on Garry Shandling’s seminal talk show satire The Larry Sanders Show. Silverman continued to hone her blithely savage comic style in clubs and on talk shows. She often adopted a cheerfully narcissistic…

Vincent Sherman: Women’s pictures: Sherman reteamed with Davis on Mr. Skeffington (1944), which was another box-office hit for the duo. The soap opera featured Davis in an Academy Award-nominated performance as a narcissistic woman who enters into a loveless marriage with a financier (Claude Rains). Less popular was Pillow to Post (1945), a screwball…

LL Cool J: …also continued to record, with Mr. Smith (1995) becoming perhaps his most commercially successful release to that date. Though subsequent albums such as 10 (2002), Todd Smith (2006), and Authentic (2013) generated the occasional hit single, in the 21st century LL found himself increasingly overshadowed by younger rappers. Nevertheless, he…

Mr. Smith Goes to Washington, American dramatic film, released in 1939, by director Frank Capra that angered the political establishment but won wide acclaim from the public and film industry. The story concerns Jefferson Smith (played by James Stewart), a hokey, idealistic youth leader who is

the Byrds: From formation to breakup: In his songs “Mr. Spaceman” and “5D (Fifth Dimension),” McGuinn, an aviation and technology enthusiast, charged the Byrds’ music and image with space-age optimism; he was also one of the first pop musicians to embrace the Moog synthesizer.

Star Trek: Kirk’s principal confidante is Mr. Spock (Leonard Nimoy), a half-human, half-Vulcan whose actions are ruled by logic almost entirely unsullied by emotion. The pointedly multicultural crew also includes “Bones” McCoy (DeForest Kelley), the ship’s irascible doctor; Lieut. Uhura (Nichelle Nichols);

Matthew Perry: Other credits: The Whole Nine Yards and The West Wing: He cocreated and starred in Mr. Sunshine (2011–12), a comedy focusing on the manager of a sports arena. The project initiated a bidding war, which was won by ABC. However, Mr. Sunshine aired for only 13 episodes before being pulled because of low ratings. In 2012–13 Perry starred as a…

Mr. T is an actor and professional wrestler known for his tough appearance and his iconic roles in television and film, including that of Sgt. B.A. Baracus in the TV action series The A-Team (1983–87). He is frequently associated with his signature catchphrase, “I pity the fool,” which originated

Columbia Records: Folk-Rock Fulcrum: …chart-topping version of Dylan’s “Mr. Tambourine Man.” The song launched the West Coast’s version of folk rock, which culminated in the Monterey Pop Festival in 1967, where Columbia’s new managing director, Clive Davis, proved willing to pay more than anyone else for new performers. By no means did all…

Milton Berle was an American comedian who, as a popular entertainer in the early days of television in the United States, came to be known as “Mr. Television.” Berle first appeared on the vaudeville stage at age 10. With his mother’s encouragement, he continued in vaudeville throughout his youth,

Today in History—May 9: Mr. Trash Wheel Goes on Duty: …a prototype, the semiautonomous, garbage-collecting Mr. Trash Wheel went into operation in the Baltimore Harbor—to great fanfare. (Including us! How can you not love him?)

Mike Leigh: The biopic Mr. Turner (2014) was an acerbic examination of the life of painter J.M.W. Turner (played by Timothy Spall). Leigh’s next film, Peterloo (2018), centres on the Peterloo Massacre (1819), in which a peaceful political rally was attacked by British forces.