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The zona fasciculata is a layer within the adrenal cortex that produces hormones called corticoids. These hormones are steroids, similar in production to sex hormones.1

The primary active hormones produced by the adrenal cortex are cortisol, corticosterone, and aldosterone. Cortisol and corticosterone are known as glucocorticoids and play a role in regulating carbohydrate metabolism, helping to maintain normal blood sugar levels. Aldosterone, a mineralocorticoid, primarily regulates sodium metabolism, influencing sodium retention and potassium excretion in the kidneys. The production of cortisol and corticosterone in the zona fasciculata is regulated by ACTH from the pituitary gland.12

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