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White matter is a component of the central nervous system, primarily found in the brain and spinal cord. It is characterized by its whitish color, which comes from the myelin sheath that insulates nerve fibers, known as axons. This myelin is composed of fatty materials, protein, and water, and it is formed by glial cells.12

The white matter lies beneath the gray matter in the brain and surrounds a butterfly-shaped area of gray matter in the spinal cord. The myelin sheath is crucial for the rapid transmission of nerve impulses, allowing them to jump between gaps in the sheath, a process called saltatory conduction. Diseases that damage this myelin, known as demyelinating diseases, can disrupt nerve function by blocking electrical impulses.324

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