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A vasodilator is an agent, such as a drug or nerve fiber, that causes blood vessels to widen or relax. This widening, known as vasodilation, increases the diameter of blood vessels, which can lower blood pressure. Vasodilators are commonly used to treat high blood pressure. They can act directly on the smooth muscle in blood vessel walls or indirectly by affecting the autonomic nervous system. Some drugs that act as calcium channel blockers also function as vasodilators because they relax the smooth muscle in blood vessel walls.1234

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