uvrABC nuclease

enzyme

Also known as: excinuclease, excision nuclease

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Last updated

July 21, 2026

Quick Summary

The uvrABC nuclease, also known as excinuclease, is an enzyme crucial for DNA repair. It specifically targets DNA damaged by UV light or certain chemicals. This enzyme works by cutting the damaged DNA strand at both ends of the damaged region, allowing for the removal of the damaged nucleotides. This process is part of a larger cellular mechanism to correct errors in DNA, ensuring genetic stability and preventing mutations. The discovery of its function in E. coli was a significant contribution to understanding DNA repair pathways.12

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Aziz Sancar
…of an enzyme known as uvrABC nuclease (excision nuclease, or excinuclease) in E. coli. The enzyme specifically targeted DNA that had been damaged by UV or chemical exposure, cutting the affected DNA strand at each end of the damaged region and thereby enabling the removal of the damaged nucleotides.
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…of an enzyme known as uvrABC nuclease (excision nuclease, or excinuclease) in E. coli. The enzyme specifically targeted DNA that had been damaged by UV or chemical exposure, cutting the affected DNA strand at each end of the damaged region and thereby enabling the removal of the damaged nucleotides.
Read More