uterine sarcoma

Uterine sarcoma is a rare but aggressive cancer that develops from the muscle or connective tissue within the uterus, distinguishing it from more common endometrial cancers which arise from the uterine lining. Sarcomas, in general, are tumors of connective tissue, unlike carcinomas which originate from epithelial tissues.12

While uterine cancer incidence is rising globally, particularly in Europe and the U.S., due to factors like obesity, uterine sarcomas are less common than endometrial cancers. Risk factors for uterine cancers often involve hormonal imbalances, such as prolonged higher levels of estrogen relative to progesterone. Symptoms can include abnormal vaginal bleeding, pelvic pain, and unexplained weight loss. Diagnosis involves biopsies and imaging, with treatment typically including surgery, radiation therapy, chemotherapy, or hormonal therapy depending on the cancer's stage and characteristics.1