unconjugated jaundice

Unconjugated jaundice, also known as hemolytic jaundice, occurs when the body produces more bilirubin than the liver can process. Bilirubin is a yellow pigment formed from the breakdown of red blood cells and muscle tissue. This condition is characterized by a yellowing of the skin and eyes.12

In unconjugated jaundice, the liver's ability to transport or conjugate bilirubin is impaired. This can happen due to the rapid destruction of red blood cells or issues with the liver's internal transport systems or enzymes. Unlike other types of jaundice, urine typically remains normal in color because the bilirubin is not water-soluble and thus not filtered by the kidneys. Stool color also usually remains normal as bilirubin still enters the intestine. This type of jaundice is common in newborns due to immature liver function and can also be a lifelong condition in some individuals, such as those with Gilbert disease.12