trypsinogen

Trypsinogen is an inactive protein precursor, also known as a zymogen, secreted by the pancreas. It is released into the small intestine, where it is converted into the active enzyme trypsin. This conversion is typically initiated by another enzyme called enterokinase, which cleaves specific peptide bonds in the trypsinogen molecule. Trypsin itself can also catalyze the activation of more trypsinogen, creating a positive feedback loop. Proteolytic enzymes like trypsin are crucial for digestion, breaking down proteins into smaller peptides and amino acids that can be absorbed by the body. The pancreas also produces a trypsin inhibitor to prevent premature activation and self-digestion.123