translocation
Quick Summary
A translocation is a type of chromosomal abnormality where a segment of one chromosome breaks off and attaches to a different, nonhomologous chromosome. This can occur during the formation of sperm or egg cells or in early embryonic development.123
While a cell with a balanced translocation may function normally, it can lead to issues during meiosis, the process of cell division that creates reproductive cells. This is because the rearranged chromosomes may not pair correctly, potentially resulting in gametes with missing or extra genetic material. These unbalanced products typically lead to inviability, making individuals with heterozygous translocations generally "half-sterile".2
Translocations are linked to certain types of human cancers, including leukemias and lymphomas. For example, the Philadelphia chromosome, a translocation associated with chronic myelogenous leukemia, fuses two genes to create a hybrid oncogene that promotes abnormal cell proliferation.4
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- chromosomal disorder
ā¦be transferred to another (translocation), which has no effect on the person in which it occurs but generally causes a deletion or duplication syndrome in his or her children. Changes in chromosome number occur during sperm or egg formation or in the early development of the embryo. In theā¦
Read Moreā¦be transferred to another (translocation), which has no effect on the person in which it occurs but generally causes a deletion or duplication syndrome in his or her children. Changes in chromosome number occur during sperm or egg formation or in the early development of the embryo. In theā¦
Read More - autosome
ā¦the autosomes also occur, including translocations of large pieces of chromosomes as well as smaller deletions, insertions, or rearrangements. Even a small deletion or addition of autosomal materialātoo small to be seen by normal karyotyping methodsācan produce serious malformations and intellectual disability.
Read Moreā¦the autosomes also occur, including translocations of large pieces of chromosomes as well as smaller deletions, insertions, or rearrangements. Even a small deletion or addition of autosomal materialātoo small to be seen by normal karyotyping methodsācan produce serious malformations and intellectual disability.
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evolutionChromosomal mutationsā¦segment is lost; or by translocation, when a segment changes from one location to another in the same or a different chromosome. These are the processes by which chromosomes evolve. Inversions, translocations, fusions, and fissions do not change the amount of DNA. The importance of these mutations in evolution isā¦
Read Moreā¦segment is lost; or by translocation, when a segment changes from one location to another in the same or a different chromosome. These are the processes by which chromosomes evolve. Inversions, translocations, fusions, and fissions do not change the amount of DNA. The importance of these mutations in evolution isā¦
Read More- heredityTranslocations
If a chromosome break occurs in each of two nonhomologous chromosomes and the two breaks rejoin in a new arrangement, the new segment is called a translocation. A cell bearing a heterozygous translocation has a full set of genes and will be viable unlessā¦
Read MoreIf a chromosome break occurs in each of two nonhomologous chromosomes and the two breaks rejoin in a new arrangement, the new segment is called a translocation. A cell bearing a heterozygous translocation has a full set of genes and will be viable unlessā¦
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oncogeneā¦occurs by the process of translocation, in which a segment of the chromosome breaks off and attaches to another chromosome. If the dislocated chromosome contains a proto-oncogene, it may be removed from its regulatory controls and be continuously produced. The excess production of protein molecules disrupts the cellular process normallyā¦
Read Moreā¦occurs by the process of translocation, in which a segment of the chromosome breaks off and attaches to another chromosome. If the dislocated chromosome contains a proto-oncogene, it may be removed from its regulatory controls and be continuously produced. The excess production of protein molecules disrupts the cellular process normallyā¦
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immune system disorderGenetic causes of cancerā¦to one mechanism, called chromosomal translocation, part of one chromosome is severed from its normal position and reattached (translocated) onto another chromosome. If a proto-oncogene appears on the piece of the chromosome that is moved, it may be separated from the region that normally regulates it. In this manner theā¦
Read Moreā¦to one mechanism, called chromosomal translocation, part of one chromosome is severed from its normal position and reattached (translocated) onto another chromosome. If a proto-oncogene appears on the piece of the chromosome that is moved, it may be separated from the region that normally regulates it. In this manner theā¦
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cancerChromosomal translocationChromosomal translocation has been linked to several types of human leukemias and lymphomas and, through comprehensive sequencing studies of the genomes of cancers, to epithelial tumors such as prostate cancer. Through chromosomal translocation one segment of a chromosome breaks off and is joinedā¦
Read MoreChromosomal translocation has been linked to several types of human leukemias and lymphomas and, through comprehensive sequencing studies of the genomes of cancers, to epithelial tumors such as prostate cancer. Through chromosomal translocation one segment of a chromosome breaks off and is joinedā¦
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