transient receptor potential subfamily A
Quick Summary
Transient Receptor Potential Subfamily A (TRPA) channels are a type of ion channel found in cell membranes. These channels are part of the larger Transient Receptor Potential (TRP) channel superfamily, which plays a crucial role in various sensory receptions, including thermoreception. Specifically, TRPA channels, along with TRPM channels, are known to respond to cold temperatures.12
When TRPA channels detect stimuli like cold, they regulate the flow of ions, such as potassium, calcium, and sodium, into or out of cells. This ion flux can cause cell membrane depolarization, leading to an action potential. This electrical signal is then transmitted as a nerve impulse, contributing to the sensation or perception of cold. TRPA channels are primarily expressed on C-fibres in peripheral nerves.12
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thermoreceptionStudy of thermoreceptorsā¦channels known as TRPM (melastatin), TRPA (subfamily A), and TRPV (vanilloid) can respond to changes in temperature, with TRPM and TRPA known to respond to cold and TRPV known to respond to warmth, noxious heat, and protons. TRPV channels have been identified on sensory neurons and on epithelial cells, andā¦
Read Moreā¦channels known as TRPM (melastatin), TRPA (subfamily A), and TRPV (vanilloid) can respond to changes in temperature, with TRPM and TRPA known to respond to cold and TRPV known to respond to warmth, noxious heat, and protons. TRPV channels have been identified on sensory neurons and on epithelial cells, andā¦
Read More- thermoreceptionProperties of thermoreceptors
ā¦thermoresponsive ion channel known as TRPA1 (subfamily A, member 1) is activated by temperatures below 18 Ā°C (64 Ā°F), which are usually reported as painful. Warm receptors are continuously active at constant temperatures above neutral skin temperature and have response maxima around 41ā46 Ā°C (106ā115 Ā°F), although, in many cases,ā¦
Read Moreā¦thermoresponsive ion channel known as TRPA1 (subfamily A, member 1) is activated by temperatures below 18 Ā°C (64 Ā°F), which are usually reported as painful. Warm receptors are continuously active at constant temperatures above neutral skin temperature and have response maxima around 41ā46 Ā°C (106ā115 Ā°F), although, in many cases,ā¦
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