thiazide
Quick Summary
Thiazide drugs are a type of diuretic that increases urine flow by reducing the reabsorption of salt and water in the kidney tubules. These drugs, synthesized in the late 1950s, are widely used to treat hypertension and are typically taken orally. They work by interfering with salt reabsorption in the distal tubule, leading to increased excretion of sodium, potassium, and chloride ions in the urine. Examples include chlorothiazide and hydrochlorothiazide.12
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pharmaceutical industryEmergence of modern diseases and treatment, the discovery of thiazide diuretics. For decreasing death and disability from cancer, one very important step was the development of cancer chemotherapy.
Read More, the discovery of thiazide diuretics. For decreasing death and disability from cancer, one very important step was the development of cancer chemotherapy.
Read More- pharmaceutical industryHypertension
…and became the first successful thiazide diuretic. While acetazolamide causes diuresis by increasing sodium bicarbonate excretion, chlorothiazide was found to increase sodium chloride excretion. More importantly, by the mid-1950s it had been shown that chlorothiazide lowers blood pressure in patients with hypertension. Over the next 50 years many other classes…
Read More…and became the first successful thiazide diuretic. While acetazolamide causes diuresis by increasing sodium bicarbonate excretion, chlorothiazide was found to increase sodium chloride excretion. More importantly, by the mid-1950s it had been shown that chlorothiazide lowers blood pressure in patients with hypertension. Over the next 50 years many other classes…
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- diuretic
…most widely used diuretics, the benzothiadiazides (e.g., chlorothiazide), interfere with the reabsorption of salt and water by the kidney tubules. Instead of being reabsorbed, the salt and water are ultimately excreted, thus increasing the flow of urine. After they were synthesized in the late 1950s, the benzothiadiazides replaced most other…
Read More…most widely used diuretics, the benzothiadiazides (e.g., chlorothiazide), interfere with the reabsorption of salt and water by the kidney tubules. Instead of being reabsorbed, the salt and water are ultimately excreted, thus increasing the flow of urine. After they were synthesized in the late 1950s, the benzothiadiazides replaced most other…
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drugRenal system drugsThe thiazide class of diuretics, which are widely used in the treatment of hypertension, interferes with salt reabsorption in the first part of the distal tubule. A mild diuresis results in which sodium, potassium, and chloride ions are eliminated in the urine. Examples of these drugs…
Read MoreThe thiazide class of diuretics, which are widely used in the treatment of hypertension, interferes with salt reabsorption in the first part of the distal tubule. A mild diuresis results in which sodium, potassium, and chloride ions are eliminated in the urine. Examples of these drugs…
Read More