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Thermoreceptors are specialized sensory receptors that detect temperature. In humans, these receptors are primarily located in the skin and are responsible for sensations of warmth and cold. Some thermoreceptors are highly specific, responding only to thermal stimuli, while others are polymodal, reacting to temperature as well as chemicals like capsaicin or menthol.1

Mammals also possess thermoreceptive elements in their brains, particularly in the spinal cord and hypothalamus, which play a role in regulating body temperature. These receptors send signals through neural pathways to the brainstem and forebrain, ultimately leading to conscious perception of temperature and influencing behaviors related to thermoregulation.234

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