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The terminal bronchiole is the final segment of the conducting zone of the respiratory system. These airways, approximately one millimeter in diameter, branch off from the bronchioles and lead into the acinus, which contains the gas-exchanging structures of the lung called alveoli.12

The walls of the terminal bronchioles lack cartilage but are lined with cuboidal epithelium containing ciliated cells and Clara cells. These cells play a role in secreting substances that help maintain the airway. The smooth muscle in the bronchiole walls can contract, potentially narrowing the airway, which is a factor in conditions like asthma. The terminal bronchioles are crucial for distributing air to the alveoli, where oxygen and carbon dioxide exchange occurs.1324

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