teratogenesis
Quick Summary
Teratogenesis refers to the production of developmental malformations in an embryo or fetus. This field of study, known as teratology, investigates all aspects of abnormal generation and development. The incidence of birth defects is significant, with about one in 14 infants surviving the neonatal period exhibiting some form of abnormality, and half of these having multiple malformations.12
Causes of teratogenesis can be hereditary, such as gene mutations, or environmental, including exposure to certain chemicals, drugs like thalidomide, alcohol, and infections. The developing embryo is most vulnerable during the first trimester, with exposure to teratogens potentially leading to growth restriction, functional abnormalities, structural defects, miscarriage, or fetal death. Organogenesis, the formation of organs, occurs at specific times, and exposure during these critical periods can result in malformations of particular organs.23
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drugReproductive system drugsā¦toxic substances are described as teratogenic (literally, āmonster-producingā). The sedative and antiemetic agent thalidomide and the anticonvulsant drug phenytoin are notorious examples of teratogens. Women frequently are advised to avoid all drugs (including nicotine) during pregnancy, unless the medicine is well-tried and essential. Drugs taken by males may be teratogenicā¦
Read Moreā¦toxic substances are described as teratogenic (literally, āmonster-producingā). The sedative and antiemetic agent thalidomide and the anticonvulsant drug phenytoin are notorious examples of teratogens. Women frequently are advised to avoid all drugs (including nicotine) during pregnancy, unless the medicine is well-tried and essential. Drugs taken by males may be teratogenicā¦
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pharmaceutical industryAdverse reactionsSome drugs will cause teratogenicity in the fetus if they are administered to the mother during this period. Drugs given to the mother during the second and third trimester can also affect the fetus by altering the function of normally formed organs or tissues. Fortunately, very few drugs causeā¦
Read MoreSome drugs will cause teratogenicity in the fetus if they are administered to the mother during this period. Drugs given to the mother during the second and third trimester can also affect the fetus by altering the function of normally formed organs or tissues. Fortunately, very few drugs causeā¦
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