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Streptokinase is a fibrinolytic drug that promotes the dissolution of blood clots. It is a proteolytic enzyme produced by streptococcal bacteria.1

Streptokinase works by activating plasminogen to form plasmin, the enzyme responsible for breaking down fibrin, a key component of blood clots. This action helps to restore blood flow in cases of acute deep-vein, pulmonary, and arterial thrombi. It is particularly effective when administered soon after a heart attack to reestablish blood flow and limit tissue damage. While effective for recent blockages, it is less successful in treating chronic occlusions. An overdose can lead to bleeding due to the breakdown of coagulation factors.21

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  1. fibrinolytic drug
  2. streptokinase

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