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The stratum spongiosum is a layer of the dermis found in amphibians. It is the outer, looser layer of the dermis, situated above the inner stratum compactum. This layer is rich in blood vessels and lymph spaces, which are important for the skin's role as a respiratory organ in many amphibians.1

In contrast, the stratum spongiosum is also described as one of the three distinct layers of the endometrium, the inner lining of the uterus. In this context, it is the middle layer, containing the main portions of uterine glands and accompanying blood vessels, with more loosely arranged stromal cells. The endometrium's layers, including the stratum spongiosum, undergo cyclical changes during the menstrual cycle in preparation for potential pregnancy.2

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