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Selegiline is a drug used to treat the symptoms of Parkinson disease and other forms of parkinsonism. It is classified as an MAO-B (monoamine oxidase B) inhibitor.1

MAO-B inhibitors work by slowing the breakdown of dopamine in the brain. Dopamine is a neurotransmitter that plays a crucial role in motor control, and its deficiency is a hallmark of Parkinson disease. By inhibiting the enzyme monoamine oxidase B, selegiline helps to extend the effects of levodopa, another common Parkinson's medication, and is often prescribed in combination with levodopa and carbidopa.12

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