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Radium-228 is a radioactive isotope of radium, which is the heaviest of the alkaline-earth metals. It is not found freely in nature but is a product of radioactive decay series, specifically the thorium series. Radium-228 has a half-life of 5.75 years.1

When radium-228 decays, it emits alpha particles, which are heavy and highly ionizing. Due to their limited penetration, alpha particles primarily affect tissues in their immediate vicinity, often leading to tumors at the site of storage. Radium isotopes, due to their chemical similarity to calcium, tend to accumulate in bones. This can cause abnormal changes in bone marrow, leading to conditions like anemia and leukemia, as well as bone cancers.2

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