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Prometaphase is a stage in cell division, specifically mitosis, that follows prophase and precedes metaphase. During prometaphase, the nuclear envelope breaks down, allowing the chromosomes to attach to the mitotic spindle. Each chromosome has two identical chromatids, and both chromatids attach to the spindle at a specialized region called the kinetochore. This attachment is crucial for ensuring that each daughter cell receives a complete set of chromosomes during cell division.1

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