prolyl hydroxylation
Quick Summary
Prolyl hydroxylation is a biological process that modifies the amino acid proline. This modification is crucial for the structure and stability of proteins, particularly collagen, a key component of connective tissue.12
In this process, a hydroxyl group (-OH) is added to proline, forming hydroxyproline. This modified amino acid is found in significant amounts in collagen, contributing to its unique strength and resilience. Hydroxyproline is synthesized within the body from glutamic acid and is not essential in the diet. Abnormal levels of hydroxyproline can be an indicator of connective tissue diseases like Marfan syndrome.13
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- William G. Kaelin, Jr.
…a chemical modification known as prolyl hydroxylation in the VHL protein facilitates cellular responses to changing oxygen availability. In the presence of oxygen, the modified VHL protein binds to another protein, known as hypoxia-inducible factor (HIF), which stimulates cell proliferation when oxygen is scarce. At normal oxygen levels, VHL binding…
Read More…a chemical modification known as prolyl hydroxylation in the VHL protein facilitates cellular responses to changing oxygen availability. In the presence of oxygen, the modified VHL protein binds to another protein, known as hypoxia-inducible factor (HIF), which stimulates cell proliferation when oxygen is scarce. At normal oxygen levels, VHL binding…
Read More - Peter J. Ratcliffe
…a chemical modification known as prolyl hydroxylation on a molecule called hypoxia-inducible factor (HIF) dictates how cells respond to changes in oxygen levels. When the modification is present, HIF is marked for degradation. When absent, HIF persists, and key cellular processes are altered to facilitate adaptation to hypoxic conditions, thereby…
Read More…a chemical modification known as prolyl hydroxylation on a molecule called hypoxia-inducible factor (HIF) dictates how cells respond to changes in oxygen levels. When the modification is present, HIF is marked for degradation. When absent, HIF persists, and key cellular processes are altered to facilitate adaptation to hypoxic conditions, thereby…
Read More