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Primary dysmenorrhea is painful cramping experienced before or during menstruation. It is caused by imbalances in the endocrine system, specifically the release of excessive amounts of prostaglandins. These substances stimulate the uterus to contract, leading to pain that can range from mild to incapacitating. Other symptoms may include fatigue, headache, nausea, and leg pain. Drugs that block prostaglandin formation can effectively manage the pain by reducing uterine contractions. Secondary dysmenorrhea, which is less common, is caused by underlying conditions such as endometriosis or pelvic inflammation.12

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