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A preganglionic fiber is an axon that originates in the central nervous system (brainstem or spinal cord) and extends to an autonomic ganglion. These fibers are part of the autonomic nervous system, which regulates involuntary bodily functions like heart rate, digestion, and gland secretion.12

In the parasympathetic nervous system, preganglionic neurons are found in the brainstem or sacral spinal cord. Their axons travel to ganglia located near or within target organs, such as the eyes, heart, or digestive tract. These neurons, along with postganglionic neurons, use acetylcholine as a neurotransmitter.34

The sympathetic nervous system also utilizes preganglionic neurons, which originate in the thoracic and lumbar spinal cord. Their axons synapse in paravertebral or prevertebral ganglia, which are generally located further from the target organs compared to parasympathetic ganglia.2

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