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polio vaccine, preparation of poliovirus given to prevent polio, an infectious disease of the nervous system. The first polio vaccine to be widely used in humans, known as inactivated poliovirus vaccine (IPV) or Salk vaccine, was developed in the early 1950s by American physician Jonas Salk. This vaccine contained killed virus and was given by injection. The large-scale use of IPV began in February 1954, when it was administered to American schoolchildren. In the following...