plasmalogen

chemistry

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July 1, 2026

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Plasmalogens are a type of phospholipid found in brain and heart tissues, and they are also synthesized in peroxisomes. These molecules are the primary ether lipids in humans, distinguished by ether linkages instead of the ester linkages common in other lipids.12

While their exact physiological role is not fully understood, defects in plasmalogen biosynthesis are linked to severe developmental conditions such as rhizomelic chondrodysplasia punctata (RCDP) and Zellweger syndrome. Reduced levels of plasmalogens have also been observed in individuals with Alzheimer disease, correlating with cognitive function deficits.2

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peroxisome
…of membrane lipids known as plasmalogens. In plant cells, peroxisomes carry out additional functions, including the recycling of carbon from phosphoglycolate during photorespiration. Specialized types of peroxisomes have been identified in plants, among them the glyoxysome, which functions in the conversion of fatty acids to carbohydrates.
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…of membrane lipids known as plasmalogens. In plant cells, peroxisomes carry out additional functions, including the recycling of carbon from phosphoglycolate during photorespiration. Specialized types of peroxisomes have been identified in plants, among them the glyoxysome, which functions in the conversion of fatty acids to carbohydrates.
Read More