phosphoenolpyruvate carboxykinase

enzyme

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July 23, 2026

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Phosphoenolpyruvate carboxykinase (PEPCK) is an enzyme that plays a crucial role in gluconeogenesis, the process of synthesizing glucose from non-carbohydrate precursors. In many organisms, including mammals, PEPCK facilitates the conversion of oxaloacetate into phosphoenolpyruvate (PEP), a key step in gluconeogenesis. This reaction requires energy, typically supplied by ATP or a similar molecule. PEPCK is also involved in the growth of microorganisms on certain carbon sources, where it helps to generate intermediates for carbohydrate metabolism. The activity of PEPCK can be regulated by the cell's energy state and the presence of other metabolites.123

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metabolism
Growth of microorganisms on TCA cycle intermediates
…this step is catalyzed by phosphoenolpyruvate (PEP) carboxykinase ([54]). Oxaloacetate is decarboxylated (i.e., carbon dioxide is removed) during this energy-requiring reaction. The energy may be supplied by ATP or a similar substance (e.g., GTP) that can readily be derived from it via a reaction of the type shown in [43a].…
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…this step is catalyzed by phosphoenolpyruvate (PEP) carboxykinase ([54]). Oxaloacetate is decarboxylated (i.e., carbon dioxide is removed) during this energy-requiring reaction. The energy may be supplied by ATP or a similar substance (e.g., GTP) that can readily be derived from it via a reaction of the type shown in [43a].…
Read More