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The perimysium is a sheath of connective tissue that surrounds and divides muscles into bundles of muscle fibers. This tissue is composed of collagen, a structural protein that provides strength and support. Within skeletal muscles, the perimysium separates individual muscles into sections called muscle bundles. These bundles are further divided into smaller muscle fibers, each wrapped in a thin connective tissue sheath called the endomysium. The perimysium, along with the epimysium and endomysium, forms the connective tissue framework of skeletal muscles.12

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