pericardial fluid

anatomy

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July 1, 2026

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Pericardial fluid is a lubricating liquid found in the pericardial cavity, the space between the two layers of the serous membrane that lines the pericardium, the sac surrounding the heart. This fluid, typically 10 to 15 ml, is secreted by the serous membranes and allows the heart to beat smoothly by reducing friction between the membranes.1

While a small amount of pericardial fluid is normal, an excessive accumulation can indicate pericardial disease, such as inflammation (pericarditis). Conditions like viral infections, autoimmune diseases, or cancer can lead to increased fluid, potentially causing cardiac tamponade, a life-threatening condition where the heart's ability to fill with blood is impaired.2

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human cardiovascular system
Pericardium
9 cubic inch) of pericardial fluid, which is secreted by the serous membranes. The slight space created by the separation is called the pericardial cavity. The pericardial fluid lubricates the two membranes with every beat of the heart as their surfaces glide over each other. Fluid is filtered into…
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9 cubic inch) of pericardial fluid, which is secreted by the serous membranes. The slight space created by the separation is called the pericardial cavity. The pericardial fluid lubricates the two membranes with every beat of the heart as their surfaces glide over each other. Fluid is filtered into…
Read More