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peptidyl-donor site
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peptidyl-donor site

biochemistry
Also known as: P site
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Quick Summary

The peptidyl-donor (P) site is a crucial location on a ribosome during protein synthesis. It's where a transfer RNA (tRNA) molecule carrying a growing polypeptide chain (a sequence of amino acids) is held. This site facilitates the transfer of the polypeptide chain to a new amino acid brought in by another tRNA at the adjacent aminoacyl-acceptor (A) site. This process, catalyzed by the enzyme peptidyl transferase, is fundamental to extending the protein chain according to the genetic code carried by messenger RNA (mRNA). Specialized tRNAs are responsible for bringing the correct amino acids to the ribosome, ensuring accurate protein assembly.12

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2 Britannica Sources
  1. metabolism - Synthesis of proteins
  2. transfer RNA

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