opioid peptide

biochemistry

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Last updated

July 1, 2026

Quick Summary

Opioid peptides are naturally occurring substances in the brain and nervous system that have pain-relieving properties. These peptides, such as enkephalins and beta-endorphins, are endogenous opioids, meaning they are produced within the body. They bind to opioid receptors, similar to how external drugs like morphine do, and are involved in regulating pain, mood, and pleasure. The discovery of these substances helped explain phenomena like the analgesic effects of acupuncture and the "runner's high". While crucial for pain management, their interaction with receptors also makes them highly addictive.12345

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hypothalamus
Hypothalamic regulation of hormone secretion
Well-known examples are the opioids (e.g., enkephalins), so named because they are endogenous (produced in the human body) peptides (short chains of amino acids) with a strong affinity for the receptors that bind opiate drugs, such as morphine and heroin.
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Well-known examples are the opioids (e.g., enkephalins), so named because they are endogenous (produced in the human body) peptides (short chains of amino acids) with a strong affinity for the receptors that bind opiate drugs, such as morphine and heroin.
Read More